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Joint Applied Math and Probability Seminar
Mathematics of Biological Sequence Analysis
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One of the key developments in biological sequence analysis during the past decade has been the emergence of graphical models as a unifying formalism for developing algorithms. Examples of graphical models that have been used include hidden Markov models for annotation, pair hidden Markov models for alignments, and tree models for phylogenetics. I will survey some of the combinatorics, algebra and geometry questions that arise in the theory of graphical models, and in their application to comparative genomics and phylogenetics. |